Depression is a potentially life threatening psychiatric disease associated with a wide range of behavioral symptoms, and accumulating clinical evidence indicates a link between psychological suffering and electrophysiological anomalies in the brain .
Clinical research supports the use of electroencephalography (EEG) in the detection of brain dysfunction in a wide range of psychiatric illnesses including depression [2, 3]. In particular, quantitative EEG (qEEG), the mathematical analysis of the raw EEG waveform using intelligent algorithms  is commonly employed in both research labs and neurofeedback clinics  for diagnostic purposes and also to monitor treatment response [6, 7]
Depression is associated with decreased metabolism in brain circuits that are key for emotion regulation (e.g., amygdala and hippocampus) and data from Q-EEG studies in adults with depression suggest that imbalances in specific EEG frequencies can be linked to both anxiety and depression symptoms.
The recording of qEEG is also employed in youth to estimate the risk for developing mood disorders  with subjects who show hypoactivation in the left frontal region of the brain being more at risk of developing depression.
Another useful measure offered by QEEG is cordance, which is obtained from a combination of absolute power (the amount of activity in a specific EEG frequency at a given electrode) and relative power (the percentage of activity for a frequency band relative to the total frequency spectrum).
Cordance can provide an estimate of antidepressant treatment response or remission with 70% or greater accuracy [9, 10] and quantitative information on white-matter lesions, metabolic changes and perfusion anomalies .
The use Q-EEG has also shown diagnostic value in patients with suicide ideation, offering support to self-report scales . For example, individuals with increased risk for suicide as measured by standard psychiatric questionnaires exhibit increased theta (4–8 Hz) and gamma activity (>30 Hz) in both frontal and central brain regions [13, 14].
Fig.1 Example of QEEG anomalies in depression
The use of qEEG for the assessment of depression and for the continued evaluation of antidepressant effects has been explored in several research studies. In this context, using qEEG technology in patients with depression may assist clinicians in the choice of the appropriate therapeutic strategy, with less of the trial-and-error approach that is usually needed until patients achieve response and remission.
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